Additional file 1: Fig. 1. Tau4Rtg2652 mice exhibit a milder but disrupted nuclear speckle staining pattern for pSRRM2. Immunostaining with SC-35 antibody demonstrates that pSRRM2 is mis-localized in hippocampal CA3 neurons of a four-month-old Tau4Rtg2652 mouse (b) and appears as diffuse cytoplasmic staining. No immunoreactivity is detectable in a four month old non-Tg mouse brain (a). Scale bars, 50 µm.
