The findings of our work, combined with the evidence from the literature, support the hypothesis that changes in the content of nuclear speckles contributes to tauopathy mediated neurodegeneration in AD. Tau-mediated neurodegeneration can be rescued in animal models by altering the content of nuclear speckles, for instance by targeting MSUT2 or related proteins [19]. Examination of the transcriptome and proteome of SRRM2 + /tau deposits and nuclear speckles in AD remain important future directions for our work investigating the molecular mechanisms of tauopathy disorders and will inform future molecular dissection of tau pathobiology.
