The association of a previously implicated OD locus, CNIH3 (3), was evaluated in the current GWAS meta-analysis of EAs. The lead SNP for CNIH3, rs10799590, was identified in a GWAS that compared opioid-dependent daily drug injectors with opioid misusers who never progressed to daily injection (5), whereas in our OD GWAS, the phenotype was OD criterion count. With that in mind, we note that the meta-analysis P-value for rs10799590 with OD criterion count was 0.038 in EAs.
