We next considered the effects of other substance use disorder criteria, including those for cocaine dependence (CD), alcohol dependence (AD), and nicotine dependence (ND), on the rs12442183 association signal. When we included CD, AD and ND criterion counts as covariates along with age, sex and first three PCs, there was decreased evidence of association of rs12442183 with OD in Yale-Penn 1-3 EAs, where nominal P-values were 3.7×10-7, 0.17, and 0.08, respectively (meta-analysis P=3.91×10-7). Thus, the effect of CD, AD and ND on the observed association of rs12442183 with OD was observable, but limited.
