The validity of the association of rs12442183 with OD in EAs and potentially also in AAs was demonstrated by the observation that 5 out of 7 cohorts (Table 1 and Figure 2) show at least nominal significance at this marker. Rs12442183 and rs1872052 (hg19 position chr15: 93752878, ∼4.9 kb downstream of rs12442183) are the only two of the top 10 signals in the EA GWAS that were also nominally associated in AAs (Supplementary Table 2). Many of the variants that were associated in EAs were not present or were uncommon in AAs, so there was no relevant information for them. The meta-analysis P-value for rs12442183 was also significant (3.0×10-8) across all cohorts (EA and AA), but the combined P-value is higher (i.e., less significant) than the European-specific P-value, which may be due to the different haplotype structures for EAs and AAs.
