The association of the lead SNP rs12442183 with OD was tested further in opioid-exposed AAs from three cohorts (Table 1), including Yale-Penn 1 (n=1506), Yale-Penn 2 (n=245) and SAGE (n=263) (MAF 0.33 in AAs). Yale-Penn 3 was not included because of the small number of AAs (n=12). Rs12442183 was significantly (P=1.2×10-2) or marginally significantly (P=8×10-2) associated with OD in Yale-Penn 1 and Yale-Penn 2, respectively. Possibly due to the same low variation of OD criterion counts in SAGE AAs, the association of rs12442183 with OD was not significant. However, by meta-analysis of the 2014 AA samples, the association of rs12442183 with OD was replicated (meta-P=3×10-3) (Table 1 and Figure 2).
