Our lead SNP for VAT in women, rs1659258, is located in an intergenic region upstream from THNSL2 and FABP1. However, rs1659258 is not in linkage disequilibrium (LD) with any coding SNPs within 88,200-88,700 kb. In addition, the correlations between rs1659258 with coding SNPs in FOXI3, C2orf51, THNSL2, EIF2AK3, FABP1, and SMYD1 genes are low (r2<0.15). Finally, there is no evidence that 2p11-p12, where rs1659258 is located, has been previously implicated in association with copy number variation in adipose-related human disease. Nonetheless, we explored the potential biology in this region. Fatty acid binding protein is produced in the liver and is involved with fatty acid metabolism. Free fatty acid flux has previously been shown to be more strongly associated with visceral as compared to subcutaneous fat [44]. In addition, women have been shown to have a faster rate of non-oxidative free fatty acid disposal as compared to men, but without concomitant worsened metabolic risk factor profiles [45]. While FABP1 represents an exciting potential candidate gene, rs1659258 resides in a neighboring linkage disequilibrium block that does not contain any genes. THNSL2 is
