fatty acid disposal as compared to men, but without concomitant worsened metabolic risk factor profiles [45]. While FABP1 represents an exciting potential candidate gene, rs1659258 resides in a neighboring linkage disequilibrium block that does not contain any genes. THNSL2 is just downstream of FABP1 and our lead SNP demonstrates nominal gene expression to THNSL2, which is part of the threonine synthase family. A recent analysis of RNA expression in 225 healthy Pima Indian skeletal muscle biopsies showed a bimodal (ie two discrete clusters) expression of THNSL2, thought to occur due to cis-acting polymorphisms [46].
