Chunk #27 — Results — Associations of CD with the positive variants identified in the EA family sample in the other three independent samples

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Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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The allele and genotype frequencies of SNP3 and SNP8 in EA and AA case-control samples are listed in Table 3. In controls, we observed that the G allele frequency of SNP3 and T allele frequency of SNP8 in AAs were significantly higher than those in EAs (PSNP3=0.006, PSNP8= 4.5×10−10).