Chunk #26 — Results — Associations of CD with the positive variants identified in the EA family sample in the other three independent samples

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Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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In the EA case-control sample, SNP3 and SNP8 were in HWE in both cases and controls. In the AA case-control sample, SNP3 was in significant Hardy-Weinberg disequilibrium (HWD) in cases (P=7.0×10−4), and SNP8 was in nominal HWD in cases (P=0.025), but both were in HWE in controls (P>0.05), which may be an indication of marker-phenotype association (Luo et al 2006).