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Chunk #13 — Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300

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Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression.
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have been quite keen to publish negative findings (6 nagative reports have appeared in the last 3 years, all of which are taking part in the meta-analysis, although curiously most positive reports appearing over this time period have not been invited to take part). Culverhouse et al. allow unpublished studies to submit data for the meta-analysis, and they report that they have trawled for these unpublished studies. As such, requiring N > 300 to prevent the file drawer problem does not seem necessary.