Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression.
paper
Cited
Public
- Authors
- Moffitt, Terrie E; Caspi, Avshalom
- Year
- 2014
- Journal
- BMC psychiatry
- PMID
- 24939753
- DOI
- 10.1186/1471-244X-14-179
- PMCID
- PMC4084794
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| # | Section | Preview |
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| 0 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression | We are delighted to see pre-study publication in BMC Psychiatry[1] of the research design and plans… |
| 1 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 1: “Primary Analysis Plan 2” to study lifetime depression does not allow for establishing temporal order between stress and depression | Primary Analysis Plan 2 in Culverhouse et al. [1] states that studies that measured stress and… |
| 2 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 1: “Primary Analysis Plan 2” to study lifetime depression does not allow for establishing temporal order between stress and depression | consequence of their mood disorder [3]. This well-known phenomenon is referred to in the literature… |
| 3 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 1: “Primary Analysis Plan 2” to study lifetime depression does not allow for establishing temporal order between stress and depression | Setting aside for the moment the question of temporal order between cause and effect, studies using… |
| 4 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 1: “Primary Analysis Plan 2” to study lifetime depression does not allow for establishing temporal order between stress and depression | proposed meta-analysis, GxE research, the poor accuracy of these retrospective recall measures is… |
| 5 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 1: “Primary Analysis Plan 2” to study lifetime depression does not allow for establishing temporal order between stress and depression | The BMC Psychiatry methods paper includes two plans. It includes Primary Analysis 1, a new separate… |
| 6 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 1: “Primary Analysis Plan 2” to study lifetime depression does not allow for establishing temporal order between stress and depression | of life events that occurred after depression. Results showed empirically that unless the stress… |
| 7 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 1: “Primary Analysis Plan 2” to study lifetime depression does not allow for establishing temporal order between stress and depression | We suspect that Plan 2 is retained solely because it offers an attention-getting large sample size.… |
| 8 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 1: “Primary Analysis Plan 2” to study lifetime depression does not allow for establishing temporal order between stress and depression | but has a larger N) will be those most likely to be highlighted by the authors, covered in the… |
| 9 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | The protocol excludes many important studies, in part because of their design features (e.g.,… |
| 10 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | are significantly more likely to be prospective-longitudinal and to utilize face-to-face interviews… |
| 11 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | features of a replication analysis as closely as possible to features of the original published… |
| 12 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | The rationale given in the Culverhouse et al. protocol for exclusion of small studies is that more… |
| 13 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | have been quite keen to publish negative findings (6 nagative reports have appeared in the last 3… |
| 14 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | Our point about sample size is not new. We explained it in our American Journal of Psychiatry paper… |
| 15 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | Culverhouse et al. include an a priori plan to test for effects of study design features on… |
| 16 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | opportunity for the Culverhouse team. In fact, our claim is not really that smaller studies are more… |
| 17 | Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression — Issue 2: The protocol excludes studies with N < 300 | These two issues that we raise here, temporal order and sample size, are not new to observational… |
| 18 | Competing interests | Through the Wisconsin Alumni Research Foundation Drs. Moffitt and Caspi hold patent “Method for… |
| 19 | Authors’ contributions | TM and AC wrote the letter and gave final approval of the version to be published. |
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Next →
| Name | Type |
|---|---|
| 5-HTTLPR | variant |
| Alzheimer’s disease | phenotype |
| Culverhouse et al. local | cohort |
| Culverhouse et al. protocol local | cohort |
| Culverhouse et al. replication project local | cohort |
| depression | phenotype |
| forthcoming meta-analysis local | cohort |
| GxE finding local | phenotype |
| intimate partner violence | phenotype |
| large studies local | cohort |
| Low birth-weight local | phenotype |
| medical illness stressors local | phenotype |
| meta-analysis | cohort |
| mood disorders | phenotype |
| parental divorce/separation | phenotype |
| Plan 2 local | cohort |
| SLC6A4 | gene |
| small studies local | cohort |
| stress | phenotype |
| stressful life events | phenotype |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | 2018 | 28373689 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Differential susceptibility effects of the <i>5-HTTLPR</i> and <i>MAOA</i> genotypes on decision making under risk in the Iowa gambling task. | Rehn M et al. | — | 2025 | → |
| Beyond orchids and dandelions: Susceptibility to environmental influences is not bimodal. | Zhang X et al. | — | 2023 | → |
| Three phases of Gene × Environment interaction research: Theoretical assumptions underlying gene selection. | Zhang X et al. | — | 2022 | → |
| Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation. | Checknita D et al. | — | 2021 | → |
| Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores. | Starr LR et al. | — | 2021 | → |
| Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women. | Rodríguez-Ramos Á et al. | — | 2019 | → |
| The developmental origins of ruminative response style: An integrative review. | Shaw ZA et al. | — | 2019 | → |
| Uncovering the Genetic Architecture of Major Depression. | McIntosh AM et al. | — | 2019 | → |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | — | 2018 | → |
| Gene-environment interaction and psychiatric disorders: Review and future directions. | Assary E et al. | — | 2018 | → |
| Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions. | Nilsson KW et al. | — | 2018 | → |
| Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging. | Zannas AS | — | 2018 | → |
| Letter to the Editor: Bias in the measurement of bias. Letter regarding 'Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression'. | Vrshek-Schallhorn S et al. | — | 2017 | → |
| Genetic Moderation of Stress Effects on Corticolimbic Circuitry. | Bogdan R et al. | — | 2016 | → |