ask (a) whether a polygenic score for alcohol consumption (average intake per week) from a population-based cohort predicts a range of drinking milestones in a sample that is enriched for familial risk for alcohol problems, (b) whether any association between the PRS and drinking milestones is moderated by age, sex, or family history of alcohol use disorders, and (c) whether the PRS is associated with aspects of drinking above and beyond the effect of the strongest signal for AUD, rs1229984 in ADH1B.
