in the COGA sample (Wetherill et al., 2015). FYB, FYN binding protein, is associated with the innate immune system and T-cell receptor signaling; rs113497429, in an intron of FYB, is suggestively associated with alcohol use disorder symptom count (Gelernter et al., 2015). Two intronic SNPs in TNFRSF10A, rs73222599 and rs73222600, were also suggestive with symptom count in African Americans (Gelernter et al., 2015) (Gelernter et al., 2014); TNFRSF10A (TNF receptor superfamily member 10a) is a receptor for the ligand Trail (TNF-related apoptosis-inducing ligand) that can mediate neuronal apoptosis (Ryan et al., 2004). FOXA3 (forkhead box A3), more highly expressed in AD and was decreased by ethanol treatment, plays a role in neuronal death after seizure-induced neuronal injury (Kim et al., 2014).
