Some genes that differ between AD and controls have prominent roles in brain function and were identified as either genome-wide or nominally significant by GWAS, making them promising targets for follow-up studies. SASH1 (SAM and SH3 domain containing 1) is a scaffold protein involved in the TLR4 signaling pathway that has been linked to the inflammation seen in chronic drinking (Crews et al., 2015; Kelley & Dantzer, 2011) and associated with unipolar depression and alcohol dependence (Zhou et al., 2017). SIX3, a homeobox gene and transcriptional regulator important during forebrain development, is associated with alcohol and nicotine codependence (Zuo et al., 2012). SLC35F3 (solute carrier family 35 member F3) is a probable thiamine transporter expressed at highest levels in brain (GTEx); an intronic variant, rs17514104, is suggestively associated with dependence on at least one substance (alcohol, cannabis, opioid or cocaine) in the COGA sample (Wetherill et al., 2015). FYB, FYN binding protein, is associated with the innate immune system and T-cell receptor signaling; rs113497429, in an intron of FYB, is suggestively associated with alcohol use disorder symptom count (Gelernter et
