For model 1 which controlled for age, sex and ancestry, we found a significant effect of PRS on positive symptoms at PT of 0.5 (R2 = 0.007, p = 0.029, empirical p = 0.029) and a significant effect on negative symptoms at PT of 1e-07 (R2 = 0.005, p = 0.047, empirical p = 0.048), though the effect on negative symptoms was not in the predicted direction (β = −180.5). Please refer to S1 Table 1 for full results. Fig. 1 shows model 1 bar plots for PRS predictions of positive symptoms and negative symptoms.
