Model 2 which additionally controlled for neurocognition showed findings in a different direction. We found a significant effect of PRS on positive and negative symptoms at higher SNP selection thresholds. Best fit PRS at PT of 0.01 predicted positive symptoms (R2 = 0.007, p = 0.013, empirical p = 0.167) and a significant effect on negative symptoms at PT of 0.1 (R2 = 0.012, p = 0.004, empirical p = 0.329) and did not survive permutation correction. Please refer to S2 Table 2 for full results. Fig. 2 shows model 2 bar plots for PRS predictions of positive symptoms and negative symptoms.
