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Chunk #20 — Results — PRS associations

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Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia.
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There were no significant effects of PRS on disorganized, depressed or excited symptom dimensions. We did not find evidence for PRS predictions of the neurocognitive composite measure or emotion recognition. Post hoc analyses of neurocognitive domains revealed a significant association of PRS with working memory (PT = 1e-05, R2 = 0.006, p = 0.035, empirical p = 0.15) and vigilance (PT = 1e-04, R2 = 0.008, p = 0.020, empirical p = 0.09) (Fig. 3), but they did not survive permutation correction.