Results from our set based analysis are presented in Tables 2 and 3. Though we had a few sets with variants that were significantly associated with symptom dimensions, no loci survived correction for multiple set comparisons. Similarly, no variants associated with neurocognition or emotion cognition survived correction. Results from our post hoc analyses of set based associations with neurocognitive sub-domains are presented in supplementary Table 3. We found that after multiple set comparison correction was applied, variant rs12706998, an intergenic variant, was significantly associated with working memory (FDR p = 0.031) and variant rs17269617, also an intergenic variant, (FDR p = 0.020) was associated with verbal memory.Table 2Associations (p < 0.05 with 10,000 permutations within each set) of quantitative psychopathology symptom phenotypes.Table 2Symptom pheno-typesLociTop variant in setp-Val in setBetaGeneRelevant biological functionaPositivechr7:137039644–137085244rs168749610.0028−0.94DGKI (Diacylglycerol kinase iota)Intracellular signal transductionchr1:30412551–30437271rs1009080b0.01580.76cchr1:177247821–177300821rs31764430.02410.71FAM5B (BMP/retinoic acid inducible neural specific protein 2)Positive regulation of neuronal differentiation, protein forms the cell component of neuronal cell bodyNegativechr11:133808069–133852969rs37589270.0031.75IGSF9B (protein turtle homolog B)G-protein coupled receptor, cell component of postsynaptic membrane, dendrite, neuronal cell body.chr11:113317794–113423994rs71150900.0111−1.05cchr18:53453389–53804154rs19600540.02281.54cchr7:110034393–110106693rs2118140.02434.26cchr2:185601420–185785420rs168261830.0274−2.44ZNF804A (zinc finger protein 804A)Implicated in several neurocognitive processeschr1:149998890–150242490rs112053340.0281−3.42PLEKHO1 (Pleckstrin
