specific protein 2)Positive regulation of neuronal differentiation, protein forms the cell component of neuronal cell bodyNegativechr11:133808069–133852969rs37589270.0031.75IGSF9B (protein turtle homolog B)G-protein coupled receptor, cell component of postsynaptic membrane, dendrite, neuronal cell body.chr11:113317794–113423994rs71150900.0111−1.05cchr18:53453389–53804154rs19600540.02281.54cchr7:110034393–110106693rs2118140.02434.26cchr2:185601420–185785420rs168261830.0274−2.44ZNF804A (zinc finger protein 804A)Implicated in several neurocognitive processeschr1:149998890–150242490rs112053340.0281−3.42PLEKHO1 (Pleckstrin homolog domain containing family O member 1)NAchr1:97792625–98559084rs107830630.02841.44DPYD (Dihydropyrimidine dehydrogenase)NAchr15:84661161–85153461rs171584410.0312−1.41ADAMTSL3 (ADAMTS like protein 3)NAchr2:146416922–146441832rs13006403b0.04130.87cDis-organizedchr7:104598064–105063064rs102497460.010.67cchr7:86403226–86459326rs2214011b0.024−1.05GRM3(Metabotropic glutamate receptor 3)G-protein coupled receptor signaling pathway, ionotropic glutamate pathway, neuro system process, neuron-neuron synaptic transmissionchr6:73132701–73171901rs2815712b0.034−0.51cchr3:52541105–52903405rs1573815b0.0495−0.56TMEM110(Transmembrane protein 110 -MUSTN1 related)Calcium channel regulator activityExcitedchr6:84279922–84407274rs168716260.00921.54SNAP91 (Clathrin coat assembly protein AP180)Intracellular protein transport, receptor mediated endocytosis, chemical synaptic transmissionchr17:2095899–2220799rs749240b0.0473−0.42SMG6 (Telomerase binding protein EST1A)Telomere maintenance, RNA stabilitychr11:123394636–123395986rs49368230.04770.038GRAMD1B (Gram domain containing protein 1)NADepressedchr19:50067499–50135399rs22889200.00520.61PRR12 (proline rich protein 12)NAchr2:193848340–194028340rs176626260.0212−1.08cchr16:58669293–58682833rs9922575b0.0459−0.41cNA-information not available.aSource: PANTHER database (http://pantherdb.org).bVariant non-significant when controlled for neurocognition.cIntergenic variants.Table 3Associations (p < 0.05 with 10,000 permutations within each set) of cognitive phenotypes.Table 3Cognitive pheno-typesLociTop variant in setp-Val in setBetaGeneRelevant biological functionaNeuro-cognitionchr8:60475469–60954469rs172799570.0059−0.47bchr15:40566759–40602237rs37843970.0210.15PLCB2 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta)G-protein coupled receptor binding signaling pathway, intracellular signal transduction; Thyrotropin, oxytocin, WNT signaling, alpha adrenergic, 5HT2 receptor signaling etc.chr2:146416922–146441832rs104969850.0258−0.26bchr1:149998890–150242490rs112053340.0309−0.55PLEKHO1NASocial cognitionchr8:27412627–27453627rs174666840.0065−0.82CLU (Clusterin)CCKR signaling mapchr12:2321860–2523731rs110621600.0081−1.22CACNA1C (Voltage dependent L type ca channel subunit alpha 1C)5HT2, Alzheimer’s disease amyloid secretase, Nicotinic acetyl choline receptor, oxytocin receptor signaling pathwayschr19:50067499–50135399rs22889200.03190.48PRRG2 (Transmembrane gamma-carboxyglutamic acid protein 2)Immune system process, proteolysis, response to stimuluschr1:149998890–150242490rs120733590.04980.66bNA-information not available.aSource: PANTHER database
