Data collection for the original subjects (Paulus et al., 2012) used three steps, following approval from the University of California, San Diego (UCSD) Human Research Protections Program. First, randomly selected 18-to-25-year-old European American (EA) and white Hispanic students received emailed questionnaires. The sample did not include Asian individuals ~40% of whom experience physiological alcohol responses that might make alcohol challenges in MRI scanners unsafe (Luczak et al., 2002), and too few minorities of other ethnic/racial groups were available to create optimally matched low and high LR pairs within the projected 120 subjects. Questionnaire items were extracted from the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) interview (Bucholz et al., 1994; Hesselbrock et al., 1999) covering demography, substance use, and major psychiatric disorders using the Diagnostic and Statistical Manual of the American Psychiatric Association, Fourth Edition (DSM-IV) (American Psychiatric Association, 2000). The initial evaluation of subjects’ LR status was based on a median split on the Self-Report of the Effects of alcohol (SRE) questionnaire (Schuckit et al., 2007, 2008). From the ~70% who responded, participants were considered for inclusion if
