The current paper reports the results of a five-year follow-up of 95% of the 120 individuals who completed the baseline fMRI protocol, 116 of whom were included in the analyses by Paulus et al (2012). The current paper evaluates three hypotheses: 1) the continuous measure of LR will correlate significantly with adverse alcohol outcomes in these subjects (an evaluation necessary to adequately evaluate Hypothesis 3); 2) fMRI patterns that were related to LR will predict future adverse alcohol outcomes; and 3) baseline fMRI patterns reflecting higher BOLD-response contrasts with placebo in subjects with low LR, especially in the insula, amygdala, and prefrontal cortex, will add to the prediction of adverse alcohol outcomes even when the low LR to alcohol is also considered.
