Chunk #55 — FINDINGS — Relation of Common Neuropathologic Indices to Clinical AD, MCI, and Level of Cognition AD, MCI, and Level of Cognition — Cerebrovascular Disease
Persons with dementia were most likely to have had cerebral infarcts and those with MCI had an intermediate number of infarctions compared to those without cognitive impairment [33]. Interestingly, while infarcts were related to all cognitive abilities, in analyses controlling for AD pathology, both infarcts overall and subcortical infarcts were strongly related to measures of episodic memory [156]. Further, AD pathology and cerebral infarcts had an additive effect on the odds of dementia. In this community based study, cerebrovascular disease was found to be more common than in clinic based series [91,157]
