Chunk #54 — FINDINGS — Relation of Common Neuropathologic Indices to Clinical AD, MCI, and Level of Cognition AD, MCI, and Level of Cognition — Alzheimer's Disease Pathology
About 90% of persons meeting clinical criteria for AD also met pathologic criteria for the disease [32,33]. However, about half of persons with MCI also met pathologic criteria for AD and a third of those without cognitive impairment met pathologic criteria for AD [33]. Further, among this group of very high functioning individuals, the presence of AD pathology was associated with deficits in episodic memory [154]. Interestingly, self-report memory complaints were also related to measures of AD pathology in analyses that controlled for depression and chronic disease [155].
