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Chunk #6 — Materials and methods — Subjects and data collection

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Association of genetic copy number variations at 11 q14.2 with brain regional volume differences in an alcohol use disorder population.
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dependence, 80% with alcohol abuse at the interview time. 70% were diagnosed with alcohol dependence and 93% with alcohol abuse at lifetime. Because such a high percentage of participants were diagnosed with alcohol dependence or alcohol abuse at lifetime, we refer to them as subjects with AUD (Claus, Ewing, Filbey, Sabbineni, & Hutchison, 2011). Subjects were otherwise healthy, with no history of severe traumatic brain injury or symptoms of psychosis reported. Demographic information was collected and multiple AUD assessments were administered to subjects in order to gauge overall AUD severity. They included: alcohol dependency score (ADS) (Skinner & Allen, 1982), alcohol use disorder identification test (AUDIT) (Barry & Fleming, 1993), impaired control scale (ICS) (Heather, Tebbutt, Mattick, & Zamir, 1993) and the average number of drinking days in the 90 day period preceding their interview (tlfb avgd). Other alcohol use assessments such as the self-rating of the effects of alcohol scale and drinking history questionnaire were also available, however a significant portion of the data was incomplete and in order to maximize the number of available subjects we chose to use this subset of assessments. Available subcategories of each assessment score are shown in Table 1. Subject’s assessments showed a