We identified several MaxDrinks associated genetic variants. Specifically, six genes/regions (SGOL1, DTWD2, NDST4, KCNB2, NR4A2 and DDC) showed significant results through GWA and meta-analysis. To our knowledge, this is the first meta-analysis that using GWA analysis of MaxDrinks as an alcohol-related phenotype. The results showed significant associations of SNPs at 3p24.3, 5q23.1, 4q26, 8q13.2, 2q24.1, and 7p12.2. The identification of specific genes influencing MaxDrinks will enable researchers to begin to decipher how the effects of these genes are modified by specific environmental influences. These findings may serve as a resource for replication in other populations and provide a foundation for future investigations.
