We have described a new method for estimating genetic correlation from GWAS summary statistics, which we applied to a dataset of GWAS summary statistics consisting of 24 traits and more than 1.5 million unique phenotype measurements. We reported several new findings that would have been difficult to obtain with existing methods, including a positive genetic correlation between anorexia nervosa and schizophrenia. Our method replicated many previously-reported GWAS-based genetic correlations, and confirmed observations of overlap among genome-wide significant SNPs, MR results and epidemiological associations.
