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Chunk #15 — Candidate gene studies: brain imaging and G × E

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Candidate and non-candidate genes in behavior genetics.
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The debate over G × E at the serotonin transporter locus is now considerably polarized [34•,35•,36•] but two recent papers are worth highlighting. First, Duncan and Keller used the pattern of publications to infer an excess of positive findings in the G × E literature [37•]. Their argument is that publication bias can be detected as a higher rate of positive results among novel findings compared to replication attempts, since journals preferentially publish positive findings for a novel genetic association. Second, one study replicated the design of the 2003 paper: a longitudinal study of a birth cohort of 1265 children born in New Zealand and studied from birth to the age of 30 [38]. The authors point out that “both studies have been conducted in the same geographic region (the South Island of New Zealand) over a similar historical period (1970–2010); both have gathered repeated-measures data on multiple sources of stress and adversity over the life course including: stressful life events, child abuse and trauma, exposure to inter-parental conflict, unemployment, violence victimisation and similar measures; and both have gathered measures