(1970–2010); both have gathered repeated-measures data on multiple sources of stress and adversity over the life course including: stressful life events, child abuse and trauma, exposure to inter-parental conflict, unemployment, violence victimisation and similar measures; and both have gathered measures of mental disorders using DSM criteria from adolescence into adulthood.” After testing 13 stress measures and 4 outcomes for G × E effects between number of 5-HTTLPR short alleles, the authors find “5 of the 52 results were statistically significant” (none become so if a correction for multiple testing is taken into consideration) but noted that “all significant tests of gene × environment interactions suggested that increasing numbers of ‘s’ alleles led to reduced sensitivity to stressful events” (i.e. the opposite direction to that predicted from the original study).
