For alcohol, cocaine and methamphetamine, lifetime and peak use and dose are highly intercorrelated (all r's > 0.85). Lifetime and peak use measures for cocaine and alcohol are also significantly correlated (r = 0.254 and r = 0.216, both p's < 0.05). Methamphetamine use measures were not correlated with either alcohol or cocaine use measures (all |r| < 0.13, all p's > 0.22). In STAA DAO, accumbens, caudate, and thalamus volumes were negatively associated with alcohol use (r's between − 0.328 and − 0.376, p's < .050, uncorrected for multiple comparisons). There was no significant subcortical volume by alcohol use associations in LTAA DAO or in either STAA or LTAA DASD. There were no associations of cocaine or methamphetamine use measures with subcortical volume measures in either STAA or LTAA DASD. Within the combined alcoholic groups, there were no associations of any subcortical volume measures with nicotine use measures (Wilks' λ7,75 = 0.91, p > .41). There were no associations of days abstinent from alcohol or any drug within any group. There were no associations of subcortical volumes with lifetime or current total psychiatric, mood, anxiety, or internalizing diagnoses.
