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Chunk #11 — Materials and Methods — Data Pre-Processing and Analysis

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Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.
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highlight). Pair-wise genetic correlations were assessed between retained phenotypes based on the intersection of QC-positive SNPs, and heatmaps were constructed to depict these relationships. For correlation coefficients returned within the bounds of the LDSC software, p-values were corrected using the Benjamini-Hochberg (BH) method for the total number of unique tests depicted in each correlation matrix. Within the main text, we describe only correlations that survived family-wise multiple-test correction. Correlations are reported as the coefficient ± standard error. For phenotype-pairs showing statistically significant genetic correlations, we re-evaluated the genetic correlations and estimated heritability using the HESS method (https://github.com/huwenboshi/hess; Shi et al. 2017)