Maternal maximum consumption was not associated with major depression or ADHD. It was significantly associated with ODD but this effect replicated only among females. However, it was associated with conduct disorder, having any disruptive disorder, and all 10 of the substance disorder and early or problematic use measures, even when adjusted for effects of maternal alcohol dependence, and all such effects replicated across cohorts. Differences between adjusted and unadjusted ORs were minimal. Adjusted ORs associated with significant effects ranged from 1.23 to 1.79, indicating a 23% to 79% increase in odds of the relevant disorder or of early substance use for each standard deviation increase in maternal maximum consumption. The effects of maternal maximum consumption on breadth of early substance experimentation and maximum drinks consumed similarly indicate that maternal maximum consumption was strongly related to both offspring outcomes net effects of maternal dependence (Table 3).
