Effects for maternal alcohol dependence were generally weaker and less consistent. Twenty of the 30 analyses conducted (13 diagnostic or use variables, one count, and one quasi-continuous measure in two cohorts) yielded significant results. Although the magnitude of association between dependence and disruptive disorders in particular was not trivial, these effects did not replicate consistently when adjusted for maternal maximum consumption. Only six of the 20 significant associations remained significant net the effects of maximum consumption, and only one (for ODD) replicated across cohorts.
