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Chunk #22 — Materials and Methods — The SCAN Database

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Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS.
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We have created an online database to serve the results of our gene-expression studies in LCLs. SCAN (SNP and Copy number ANnotation database; http://www.scandb.org) can be queried through either the SNP or gene to retrieve information on the relationship between SNPs and transcript levels at user-specified p-value thresholds [9]. SCAN enables batch queries of genes to retrieve a list of SNPs that predict the expression of the genes at a user-specified threshold. SCAN also holds multi-locus disequilibrium measures [28] to summarize reported LD information among SNPs and to characterize coverage of genes by the high-throughput genotyping platforms.