Despite the high level of overall correlation between PTSD and depression, we also note certain areas of clear distinction. When we examined local genetic correlations between PTSD and depression within all significant loci from the EA PTSD GWAS, we found that there were some regions with significant local heritability for PTSD but not depression, suggestive of PTSD-specific signals. In contrast, we also find other regions with clear shared signals showing local correlation across depression and PTSD, indicating that we have the power to detect shared and distinct local heritability. Together these findings suggest several PTSD-specific loci worthy of further investigation.
