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Chunk #36 — Discussion

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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
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in size and power, the field is seeing relatively strong genetic correlations among these traits, as well as with other behavioral and medical traits. This likely reflects, in part, the reality that there is substantial shared genetic variance among these traits, while not excluding the consistent observations that: (1) these traits do vary considerably in the magnitude of their genetic correlations, and (2) local genetic correlations reveal even greater genetic heterogeneity among these traits than global genetic correlations alone would lead us to believe. Finally, while PTSD is the most well-understood psychiatric outcome of trauma exposure, it is well documented that trauma is a risk factor for many different psychiatric disorders, with perhaps depression as the highest risk. Thus, these shared areas of overlap may represent general trauma vulnerability as well.