Meta-analyses of the ADHD GWAS with each replication study identified 10 genome-wide significant loci (P < 5 × 10−8, without multiple testing correction) in meta-analysis with deCODE, 10 significant loci with 23andMe, and 15 significant loci with EAGLE/QIMR (Supplementary Data 6, Supplementary Figures 21–22). Of the 12 significant loci from the primary ADHD GWAS, four were significant in all three of these replication meta-analyses: index variants rs11420276 (ST3GAL3/PTPRF), rs5886709 (FOXP2), rs11591402 (SORCS3), and rs1427829 (intergenic). The remaining loci were all significant in at least one of the replication meta-analyses. In addition, ten novel loci reached genome-wide significance in the replication meta-analyses, of which three loci were significant in two of these analyses (Supplementary Data 6): index variants rs1592757 / rs30266 (Refseq LOC105379109), rs28452470 / rs1443749 (CADPS2), and rs2243638 / rs9574218 (RNF219-AS1). The CADPS2 locus has recently been identified in autism spectrum disorder as a novel locus shared with educational attainment93.
