of the REGARDS, GenHAT, and Warfarin (see below) studies, we compiled a set of non-monomorphic and non-multi-allelic SNPs with MAF >1% that were genotyped as part of those studies. This yielded a total of 2,204,415 SNPs that were used as fence post markers for imputing the HyperGEN cohort using version r2 of the NHLBI TOPMed reference panel. Imputed variants were inspected for their imputation quality scores (R2) and it was noted that more than 99% of the variants with MAF >1% had an imputation quality >0.6. High-quality genotype calls with genotypic probability >0.9 were retained.
