(Boffetta and Hashibe, 2006; Druesne-Pecollo et al., 2009). For example, excessive alcohol intake is one of the important risk factors for colorectal cancer (Orbell and West, 2010). In addition, the functional variants in genes involved in alcohol metabolism might result in differences between individuals in exposure to carcinogenic acetaldehyde, suggesting a possible interaction of genetic susceptibility and alcohol exposure in cancer (Druesne-Pecollo et al. 2009).
