signals, the shorter isoform, are detected in interphase and mitotic cells while sSGO1 plays an essential role in protecting centriole cohesion (Wang et al. 2008). In 2008, Yamagishi et al. (2008) demonstrated that the recruitment of SGOL was the important primary role for centromeric heterochromatin in ensuring eukaryotic chromosome segregation. Uncharacterized interphase functions of SGOL1 at the centromeres may be regulated by interaction between heterochromatin protein 1 (HP1) and SGOL1 (Kang et al., 2011). Till now, no association between SGOL1 gene and any psychiatric disorders and related phenotypes has been found. SGOL1 has also been identified to be strongly overexpressed in breast cancer and had higher splice indices in malignant tumors than in benign tissues (Andre et al., 2009). Recently, Kahyo et al. (2011) reported that chromosome instability was more likely in SGOL1-downregulated colorectal cancer and there was an association between SGOL1 variant and colon cancer. It has been reported that alcohol consumption is an important cause of cancer worldwide (Boffetta and Hashibe, 2006; Druesne-Pecollo et al., 2009). For example, excessive alcohol intake is one of the important risk factors for colorectal cancer (Orbell and West, 2010). In addition, the functional variants in genes involved in alcohol metabolism might result
