In order to maintain uniformity in individual analyses, SHS compiled detailed instructions and distributed these to the groups analyzing family data with information to Z-score AOS or AOI in SAS (SAS Institute, Cary, NC) and R (http://www.r-project.org/), to code additively with a consistent minor allele, and to perform the analyses in PLINK with the –qfam-total option. Results were returned to SHS.
