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Chunk #16 — Methods — Statistical Analyses — Meta-Analyses

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Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.
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Meta-analysis was carried out using the meta-analysis procedure in PLINK [Purcell et al., 2007]. This procedure requires results files (for a quantitative trait) with beta estimates, standard errors, and an optional P-value. PLINK meta-analysis output includes a beta summary estimate, and a summary P-value for both random and fixed effects models. The R package rmeta was used to create forest plots.