proband (>=18 y)SADS-LA; Y-BOCS; LOI; FICS; YGTSSAll+ K-SADS, CY-BOCS, if childyyDSM-IVy8037 (18–88)7339 (18–79)32629738 (11.7)8 (2.7)53 (16.3)17 (5.7)Black et al. [25]USAAdult probandSCID- IV; Y-BOCS; SIDP-IV; FAD*Offsprings (child between ages 7 and 18 years)DICA, CBCL for childrenyyDSM-IVy2139.5 (6.4)2238.2 (5.6)433510 (23)1 (3)13 (30)8 (23)Fyer et al. [26]USAAdult probandSADS-LA, FISCSameyyDSM-III-Ry7234.8 (11)3243.6 (15)17911211 (6.2)0 (0)15 (8.4)0Lipsitz et al. [27]USAAdult probandSADS-LA, FISCSameyyDSM-IVy5737.2 (13)4142.6 (13)1121154 (3.6)2 (1.7)6 (5.4)2 (1.7)Grabe et al. [28]GermanyAdult proband (>=18)SADS-LASameyyDSM-IVn10538.3/44.87042.1 (16.4)34324722 (6.4)3 (1.2)197Bienvenu et al. [5]*Johns Hopkins OCD Family Study*OCD Collaborative Genetics StudyUSAAdult probandSADS-LA; SCID-IVAll those + K-SADSyyDSM-IVy382Not reported73Not reported974233524 (55)16 (7)Nationalwide register-based studiesFull sibling(OR)Parent(OR)Offspring(OR)Mataix-Cols et al. [7]Swedenall psychiatric patients treated in Sweden(1969–2009)Swedish National Patient RegisterSamennICD-10n24768135898195.03 (4.49–5.64)4.70 (4.09–5.40)4.56 (3.97–5.24)Full sibling (OR)Maternal (OR)Paternal (OR)Offspring(OR)Steinhausen et al. [8]DenmarkAll individuals born between 1952 and 2000Danish Psychiatric Central Research RegistersamennICD-8ICD-10y205760556.19 (6.65–10.49)11.21 (3.14040.04)34.04 (4.42–262-39)4.54 (1.28–16.13)Full sibling(RRR)Browne et al. [9]DenmarkAny individuals who had contact with the national health care system (1969–1995)Danish Psychiatric Central Register; Danish National Hospital RegistersamennICD-8ICD-10n619117346684.89 (3.45–6.93)Full sibling(OR)Maternal half siblings (OR)Paternal half siblings (OR)Twins (OR)Brander et al. [10]SwedenAny individuals born between 1967 and 2007Swedish national registerssamennICD-8ICD-9ICD-10n22232406313510.63 (7.92–14.27)3.72 (1.92–7.20)0.30 (0.04–2.12)25.19 (9.20–68.98)Full sibling(RRR)Maternal half siblings (RRR)Paternal half siblings (RRR)Mahjani et al. [11]SwedenAny individuals born between 1982 and 1990Swedish Medical Birth RegistersamennICD-10n71848156594.82 (4.03–5.62)1.85 (0–2.37)1.09 (0–1.96)Full sibling(RR)Parents (RR)Offspring (RR)Twins (RR)Huang et
