Chunk #27 — Results — Family studies

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The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis.

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disorders assessment toolsDiagnosis criteria and controlSample sizeDiagnosis in first-degree relativesAuthor/yearCountryProband age inclusion criteriaProbandRelativesBlind to proband status (y/n)Best estimate diagnosis procedure (y/n)Diagnostic criteriaControls matched for gender and age (y/n)ProbandFirst-degree RelativesDefinite OCDProbable OCDDefinite/Probable OCDCaseControlCaseControlCaseControlCaseControlCaseControlnMean age (SD)nMean age (SD)nnnnnnnnChild probandReddy et al. [20]IndiaJuvenile proband (<=16 y)DICA-R; CV-LOI; CY-BOCS. questionnaire for ticSame if child; SCAN, LOI, Y-BOCS, questionnaire for tic disorder, if adult.nyDSM-III-Ry3513.6 (2.4)341069440Hanna et al. [21]Hanna et al. [22]USAAdolescent proband (10–17 y)K-SADS-E; STOBSSCID-III-R, Y-BOCS, FISC; STOBSyyDSM-III-Rn3513.7 (2.4)1712.4 (1.8)1023923 (22.5)1 (2.6)28 (27.4)1 (2.6)Rosario Campos et al. [17]USAChildren and adolescent proband (<=18 y)STOBS; Y-BOCS; YGTSS; KSADS; SCIDSameyyDSM-IVy10611.9 (3.03)4411.2 (2.06)32514062 (22.7)1 (0.9)79 (29.2)3 (2.4)Adult probandMcKeon and Murray [65]USAAdult probandSADS-LSADS-L; SAPn–Research Diagnostic Criteria (RDC)y50Not reported50Not reported14915111Black et al. [66];Black et al. [4]*Iowa family study of OCDUSAAdult probandSADS; Y-BOCS; NIMHOCS; Hamilton Depression Rating ScaleDIS; SIDP; FHRDCy–DSM-IIIy3237.9 (10.9)3338.4 (10.2)1681841 (0.6)1 (0.5)Pauls et al. [16];Carter et al. [29]USAAdult probandSTOBS; DIS; K- SADS-E; Y-BOCSSameyyDSM-III-Rn10033.6 (12.1)33466113472352824Bienvenu et al. [67];Nestadt et al. [18];Grados et al. [23];Nestadt et al. [24]*Johns Hopkins OCD Family StudyUSAAdult proband (>=18 y)SADS-LA; Y-BOCS; LOI; FICS; YGTSSAll+ K-SADS, CY-BOCS, if childyyDSM-IVy8037 (18–88)7339 (18–79)32629738 (11.7)8 (2.7)53 (16.3)17 (5.7)Black et al. [25]USAAdult probandSCID- IV; Y-BOCS; SIDP-IV; FAD*Offsprings (child between ages 7 and 18 years)DICA, CBCL for childrenyyDSM-IVy2139.5 (6.4)2238.2 (5.6)433510 (23)1 (3)13 (30)8