Chunk #230 — VIII. A possible underlying neurobiology: connectivity constellations — B. Quality and/or quantity of connections involved in vulnerabilities
C. Overlapping effects of “connectivity constellation” gene variants, comorbidities and co-occurance frequencies. One of the predictions that comes from postulates that variants in a limited number of genes contribute to genetic components of susceptibility to a variety of phenotypes is the prediction that these phenotypes would occur together more often than expected by chance. The magnitude of co-occurance, of course, would be expected to differ based on differential penetrance of each locus on each phenotype as well as other factors.
