Hepatocyte RXRα-deficient mice possess a phenotype partially overlapping both PPARα and PPARγ knockout-mice phenotypes. Like the PPARα-null mice, hepatocyte RXRα-deficient mice are obese, have a larger fat mass, and higher serum cholesterol and leptin levels compared with wild-type mice; similar to PPARγ +/− mice, hepatocyte-RXRα-deficient mice also have reduced food intake and increased serum leptin levels [98]. On the contrary, hepatocyte RXRα deficiency results in an improved glucose tolerance without altering insulin level or insulin sensitivity [98].
