RXRα deletion increases liver enzymatic activity of ADH1 isoform without affecting ADH2 and ADH3 [12]. It has been suggested that RXRα may regulate ADH1 translation because mRNA levels were the same between null and wild-type mice, while there is increased abundance of ADH1 mRNA in the polysome fraction, indicating higher translation in null mice. This latter effect may be mediated by leptin whose levels are increased in RXR null mice [98] and has been reported capable of regulating ADH activity [99].
