Independent t-tests conducted on the full sample (i.e, AA and EA subjects) revealed significant differences by sex for maxdrinks (t(3786.3)=18.52, p<0.0001) and AUD symptoms (t(3581.5)=10.53, p<0.0001). Women reported a mean of 16.3 (SD=13.2) drinks, and men reported a mean of 24.3 (SD=14.1) drinks. Means for AUD symptoms were 4.3 (SD=3.8) and 5.6 (SD=3.6) for women and men, respectively. Sex differences were also observed for exposure to childhood adversity in the full sample; the prevalence was significantly higher in women than men (OR=1.25, CI: 1.10–1.41): 39.1% vs. 34.0%. The final models, which included ADH1B by childhood adversity interaction effects, were therefore conducted separately for AA women (n=1,131), AA men (n=1,486), EA women (n=586), and EA men (n=850). The prevalence of A-allele carriers and exposure to adverse events in childhood are shown by race/ethnicity and sex in Table 2.
