The prevalence of rs1229984 A-allele carriers was 3.1% in the AA subsample (minor allele frequency (MAF) =1.6%) and 11.5% in the EA subsample (MAF=6.5%). The prevalence of rs2066702 A-allele carriers was 30.6% in the AA subsample (MAF=19.7%) and 1.2% in the EA subsample (MAF=0.07%). Ordinal logistic regression analyses revealed that EA carriers of the rs1229984*A allele reported fewer maxdrinks (OR=0.42, CI:0.30–0.58) and AUD symptoms (OR=0.34, CI:0.25–0.45) than noncarriers. In the AA subsample, no significant association between rs1229984 and either alcohol outcome was observed, but there was evidence of a protective effect for the rs2066702*A allele. Fewer maxdrinks (OR=0.69, CI: 0.59–0.80) and AUD symptoms (OR=0.67, CI:0.58–0.78) were reported by A-allele carriers than noncarriers. No significant association between rs2066702 and either alcohol outcome was observed in the EA subsample. Ordinal logistic regression analyses testing for GxE effects were therefore conducted with the rs2066702 SNP in the AA subsample and the rs1229984 SNP in the EA subsample. Logistic regression analyses conducted to test for gene–environment correlations (i.e., rs1229984 or rs2066702 with childhood adversity) revealed no association of either SNP with exposure to adverse childhood events.
