differences in mean maxdrinks and AUD criteria, and a logistic regression analysis was conducted to assess distinctions by sex in risk for exposure to childhood adversity. Fourth, based on findings from preliminary analyses (reported in the Results section), ordinal regression analyses were conducted separately by sex and population, using rs2066702 in the AA female and AA male models and rs1229984 in the EA female and EA male models. Age was included as a covariate, and models were adjusted for nonindependence of observations in family members using the clustered sandwich estimator. We applied a Bonferroni correction to account for multiple testing within each group (i.e., AA women, AA men, EA women, and EA men) such that the threshold for significance was set to 0.025.
